METABOLIC ENGINEERING TO SIMULTANEOUSLY ACTIVATE ANTHOCYANIN AND PROANTHOCYANIDIN BIOSYNTHETIC PATHWAYS IN NICOTIANA SPP.

Metabolic engineering to simultaneously activate anthocyanin and proanthocyanidin biosynthetic pathways in Nicotiana spp.

Proanthocyanidins (PAs), or condensed tannins, are powerful antioxidants that remove harmful free oxygen radicals from cells.To engineer the anthocyanin and proanthocyanidin biosynthetic pathways to de novo produce PAs in two Nicotiana species, we incorporated four transgenes to the plant chassis.We opted to perform a simultaneous transformation of

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Geranylgeraniol Application in Human Osteoblasts and Osteoclasts for Reversal of the Effect of Bisphosphonates

Nitrogen-containing bisphosphonates lead to the depletion of geranylgeranyl pyrophosphate involved in the mevalonate pathway.The effect of geranylgeraniol (GGOH) on human osteoblast and osteoclast Trays activities suppressed by zoledronate was investigated in this study.The effect of GGOH on human osteoblasts and osteoclasts subjected to treatment

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Traffic flow forecasting using natural selection based hybrid Bald Eagle Search-Grey Wolf optimization algorithm.

In a fast-moving world, transportation consumes most of the time and resources.Traffic prediction has become a thrust application for machine learning algorithms to overcome the hurdles faced by congestion.Its accuracy determines the selection and existence of machine learning algorithms.The accuracy of such an algorithm is improved better by the p

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